Nowadays assessment of fatigue and reliability of structures have increased dramatically. This is confirmed by the recommendations of the standards and constitutive model of concrete in which the rules and requirements to ensure safety, serviceability and durability of the structure are stated. This study is directed to the reliability assessment of reinforced concrete column and fatigue comparison of (BS:8110, 1997) and Eurocode 2 (EN:2, 2004) ultimate limit state requirements on nominal eccentricity of short column resisting moments and forces. The column was modeled as one end fixed to resist moment reaction and free at the other end. It was then examined on fatigue and probabilistically assessed with the variables relating to the uncertainty loading conditions. The First-Order Reliability Method (FORM 5) encoded in CalREL was employed to estimate the implied probability of failure by varying load ratio and reinforcement ratio. And was verified with numerical simulation on CONCRETE MODEL OF 3 Dimension (COM 3). The results obtained have shown that the column assessed lost its flexural and shear carrying capacity gradually as the percentage load increased especially at the joint. Reinforced concrete column’s performance may be dependent on the applied load and could fail if it carries a lot more than the designed loads. It is therefore necessary to perform fatigue investigation to double check the resistant capacity of the column.